KRAS and metastatic neoplasm: Although there is no difference between the survival of KRAS mutant primary tumors and KRAS wild-type primary tumors, KRAS mutant metastatic tumor showed poorer survival versus their KRAS wild-type counterparts (P=4.285 × 10−6) (Figure 2), further suggesting the importance of KRAS mutation detection in the clinical management of metastatic tumors.