Besides from the high prevalence of missense/truncating mutation, two inframe mutations (G13dup and Q61_S65dup) were found in metastatic tumor tissues originated from mesonephric carcinoma and PAAD respectively, and the KRAS-SOX5 gene fusion was also identified in a metastatic tumor with unknown primary (Figure 1(c)). The gene discussed is SOX5; the disease is pancreatic adenocarcinoma.