In our study, we found that the decreased expression of miRNA-27b-3p in dust mite-induced pediatric asthma as well as the increased expression of SYK. We speculated the decreased expression of miRNA-27b-3p may reduce the degradation of the target gene SYK, which then alters the activity of PI3K and affects the production of cytokines, finally leading to an asthma attack. This evidence concerns the gene SYK and childhood onset asthma.