EGFR and asthma: In our study, we have also found the decreased expression of miRNA-27b-3p and increased expression of SYK and PI3K. As a target gene of miRNA-27b-3p by miRDB analysis, the expressions of SYK and PI3K (a downstream gene of SYK and EGFR in the PI3K-AKT pathway) were significantly increased in the asthma group compared with the control group (p < 0.05).