Later on, a mechanistic study using chromatin immunoprecipiation and DNA sequencing demonstrated that in neuroblastoma, LMO1 could affect LIMSI (LIM and senescent cell antigen-like domains 1), Ras suppressor protein 1 (RSU1), and relaxin 2 (RLN2) gene, and regulate a carcinogenic LIMSI/integin-linked kinase pathway (33). This evidence concerns the gene RLN2 and neuroblastoma.