Additionally, elevated AGR2 protein expression is observed in numerous cancer types including gastric adenocarcinoma (19), breast (20), non-small cell lung (21), ovarian (22, 23), esophageal, prostate, and pancreatic cancer (24), and overexpression of the AGR2 protein is correlated with poor prognosis in these carcinomas. Here, AGR2 is linked to familial pancreatic carcinoma.