SNV of CTLA-4 are implicated in clinical response and survival in melanoma patients (41, 42) and, more recently, SNV-1577G > A and SNV CT60G > A were linked to a better response to Ipilimumab in a 173-patients cohort (43) and SNV-1661A > G to the onset of endocrine adverse events (44). This evidence concerns the gene CTLA4 and melanoma.