Additional validation for the positive impact of physical activity on stroke risk, as well as the degree of insult, was revealed in a subanalysis of data from a randomized clinical trial done in 2017 where patients with high pre-stroke physical activity (mainly treated with t-PA) had a reduction in the size of infarct growth in 24 hours, as well as the final infarct size [9]. The gene discussed is PLAT; the disease is stroke disorder.