TAC1 and neuropathic pain: It binds to the alpha-2-delta subunits of voltage-gated calcium channels to block calcium influx, resulting in reduced release of excitatory neurotransmitters such as glutamate, norepinephrine, substance P, and calcitonin gene-related peptide.9 This mechanism of action led to the use of pregabalin in disorders such as neuropathic pain, epilepsy, and anxiety.9,10,11