TERT and neoplasm: In our case, telomerase vaccine-therapy leads to high expression of telomerase in cancer treatment in-vitro and in-vivo manner and as a tumor neo-antigen to stimulate the cancer cells deaths since it is reported that TERT is a tumor-associated antigen (TAA) which caused antitumor CD8+ cytotoxic lymphocyte (CTL) response in several types of tumor [247].