Because telomerase consists of catalytic subunit telomerase reverse transcriptase (TERT), Telomerase RNA component (TERC) and telomerase complex associated protein, upregulation of telomerase expression is correlated with increasing of copy number of hTERT which is strongly positive in tumor cell [112] and correlated with telomerase activity, cancer initiation and progression [113–115]. Here, TERT is linked to neoplasm.