TNFSF10 and cancer: For example, a scFv against Kv 10.1 (EAG1), a member of the ether-à-go-go (EAG) family of potassium channels frequently expressed in human cancers, has been raised and fused to the human soluble tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), showing a selective pro-apoptotic activity on Kv 10.1 positive cancer cells [12].