Among albumin-based systems in clinical trials, Aldox (the albumin-binding Dox, also known as INNO-206 or DOXO-EMCH) has been very successful, exhibiting a good profile in a phase 3 study in soft tissue sarcoma and in phase 2 studies in small cell lung cancer, Kaposi’s sarcoma and GBM. The gene discussed is ALB; the disease is soft tissue sarcoma.