It is well established that VEGF plays an important role in tumor angiogenesis by activating the proliferation and migration of endothelial cells during micro-vessel formation [43], and correspondingly we found that VEGF probably contributes to the growth of breast tumors both directly through its action on cancer cells and through its effect on angiogenesis as shown by a drastic reduction in blood vessel formation. Here, VEGFA is linked to neoplasm.