Previous studies have demonstrated that the effects of Pimozide on neurologic diseases are via antagonism of DRD2 [32], indeed, DRD2 is expressed in various cancer types [33, 34] and has been involved in regulating Wnt and AKT signaling [35] therefore, we postulate based on the data herein that the reduction of AKT signaling and AKT gene expression by Pimozide may result from inhibition of DRD2 receptor. This evidence concerns the gene DRD2 and nervous system disorder.