STAT3 and cancer: It has also been shown that the neuroleptic agents Pimozide and Thioridazine inhibit cancer growth in culture [17], either by targeting STAT3/STAT5 signaling pathways [18, 19] or by disrupting the Wnt/β-catenin signaling pathway [20] and more recently another group [29] reported that Pimozide kills lung, breast, and brain cancer cells in vitro [30], In this study we have attempted to elucidate further the mechanism underlying these clinical observations and identify a novel biological function for Pimozide.