Our results on this SNP are very exciting given that GPR56 contributes to AML development and its expression has been associated with inferior outcome in AML.[18, 20] rs75400242 G>A (P=2.1x10-5) SNP is located in a region upstream of IGF1R (Insulin like growth factor receptor) a gene expressed in human leukemia cell lines with pathological significance in AML [21–23]. This evidence concerns the gene ADGRG1 and acute myeloid leukemia.