MN1 overexpression has been reported to be an important step in the development of inv(16) AML, and is predictive of poor outcome in AML patients with normal cytogenetics.[24, 25] An intronic SNP, rs545375 A>G (P=7.67x10-5), in opioid binding protein/cell adhesion molecule like (OPCML) occurs in high LD (r2=0.93, D’=1) with rs540923, which is an eQTL for Homeobox A10 (HOXA10), a well-known myeloid leukemia gene. The gene discussed is OPCML; the disease is acute myeloid leukemia.