ADGRG1 and acute myeloid leukemia: [31] GPR56 is also part of the 17 gene leukemic stem cell score (LSC17) that has been recently shown to have prognostic significance in predicting therapy resistance and relapse risk.[32] Saito et al. showed greater GPR56 expression in AML samples with high ecotopic viral integration site-1 expression (EVI1high), which is considered a refractory type with poor prognosis.