Biomarkers can be divided in three main categories: A, T, and N, where the first two categories include biomarkers that measure the brain amyloidosis and tauopathy, respectively, e.g., amyloid and tau tracer PET (positron emission tomography) scans, and CSF concentrations of Aβ142 and P-tau and category N encompasses biomarkers that measure neurodegeneration or neural injury (e.g., CFS T-tau, FDG PET, and atrophy in MRI) [13]. The gene discussed is MAPT; the disease is tauopathy.