These results are mostly consistent with previous studies showing that lower serum HBsAg, HBV DNA, and platelet count [39–42] and higher AFP, AST, globulin, GGT, laminin, and IV-C levels [29, 42–45] are associated with significant fibrosis in chronic hepatitis B patients. The gene discussed is ST6GALNAC4; the disease is chronic hepatitis B virus infection.