Patients with significant liver fibrosis (F2–4), in comparison with nonsignificant fibrosis (F0–1), had lower HBV DNA, HBsAg, HBeAg, and platelet count levels and higher anti-HBc, AFP, AST, globulin, GGT, laminin, IV-C, LSM, and spleen thickness. This evidence concerns the gene KRT88P and Hepatic fibrosis.