AFP and Hepatic fibrosis: Compared with nonsignificant fibrosis patients (F0–1), patients with significant liver fibrosis (F2–4) had lower HBV DNA, HBsAg, HBeAg, and platelet count levels and higher anti-HBc, alpha-fetoprotein (AFP), AST, globulin, GGT, laminin, IV-C, LSM, and spleen thickness (Supplementary Table 1).