Of these 15 hub genes, PHLPP2, DLG4, and MYC displayed significant positive correlation with overall survival while TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1 negatively correlated with overall survival in patients with glioma. This evidence concerns the gene MAD2L1 and central nervous system cancer.