Recently, we carried out a metabolomics study to elucidate therapeutic mechanisms of α-mangostin (MAN, a mangosteen derived prenylated xanthone) on experimental arthritis and found that MAN compromised the biosynthesis of nicotinamide adenine dinucleotide (NAD) in fibroblast-like synoviocyte (FLS) via downregulation of nicotinamide phosphoribosyltransferase (NAMPT, a rate-limiting enzyme in the salvage pathway) and subsequently protected the joints from destruction (unpublished). The gene discussed is NAMPT; the disease is Arthritis.