The main risk factors include aging, genetics (presenilin 1 (PSEN1), PSEN2, and APP1 genes) [7, 10], hypertension, diabetes, hypercholesterolemia, stroke, obesity, sedentary lifestyle, depression, low socioeconomic status, and alcohol and tobacco use [1, 4, 9]. The gene discussed is PSEN1; the disease is depressive disorder.