MAPT and amyloidosis: In a recently published study on APPswe/PS1ΔE9 mice, researchers were unable to demonstrate the presence of amyloid plaques, dystrophic neurites, neuronal loss, macro- or microgliosis, aberrant cell cycle re-entry, OS, tau hyperphosphorylation, or upregulation of proinflammatory cytokines or stress signaling molecules in the retina [56].