FGF10 and breast carcinoma: Finally, the regulatory subunit of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) p85 which is known to be indirectly recruited to FGFR via the FRS2/GRB2/GAB1 complex (Ong et al., 2001), has been shown to bind to phosphorylated Y734 on FGFR2b upon FGF10 stimulation in epithelial breast cancer cells (Francavilla et al., 2013).