Finally, the regulatory subunit of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) p85 which is known to be indirectly recruited to FGFR via the FRS2/GRB2/GAB1 complex (Ong et al., 2001), has been shown to bind to phosphorylated Y734 on FGFR2b upon FGF10 stimulation in epithelial breast cancer cells (Francavilla et al., 2013). This evidence concerns the gene FGF10 and breast cancer.