FGF22 and gastric cancer: Bemarituzumab (2018) (FPA144) is an anti-FGFR2b humanized monoclonal antibody currently in Phase I clinical trials as a monotherapy for FGFR2b-amplified gastric cancers. Bemarituzumab prevents the binding of FGF10, FGF7 and FGF22 to the FGFR2b and is reported to also promote antibody-dependent cell-mediated cytotoxicity through the recruitment of natural killer cells to the tumor (Bemarituzumab (FPA144) | Gastric Cancer | Five Prime Therapeutics).