Given the large number of studies on these mutations and their impact on cancer progression, several targeted inhibitors of the mutant form of IDH1 or IDH2 have been developed and have now reached the clinical trial stage (Table 2; DiNardo et al., 2016; Popovici-Muller et al., 2018; Yen et al., 2017, 2018). This evidence concerns the gene IDH2 and cancer.