Many genes were identified to be significantly associated with POAG, such as CDKN2B-AS1 (cyclin-dependent kinase inhibitor 2B antisense RNA 1) (Burdon et al., 2011, 2012), TMCO1 (transmembrane and coiled-coil domain 1) (Burdon et al., 2011; Wiggs et al., 2012), SIX1-SIX6 (sin oculis homeobox 1/sin oculis homeobox 6) (Fan et al., 2011; Wiggs et al., 2012), ATOH7 (atonal bHLH transcription factor 7) (Ramdas et al., 2011), TGFBR3-CDC7 (transforming growth factor beta receptor 3- cell division cycle 7) (Khor et al., 2011; Li et al., 2015), and et al. Here, SIX1 is linked to open-angle glaucoma.