Therefore, all the gene loci (TGFBR3-CDC7, TMCO1, CDKN2B-AS1, ATOH7, and SIX1/SIX6) included in our study were either associated with POAG or the subphenotype of POAG, such as VCDR and IOP, and were likely to contribute to the development of POAG by given genetic evidences and functional data. The gene discussed is TMCO1; the disease is open-angle glaucoma.