ALK and neuroblastoma: Several recurrently mutated genes or loci which correlated with high-risk neuroblastoma have been identified, such as ALK (Mosse et al., 2008) mutations or amplifications, PHOX2B (Brodeur et al., 1984) mutation, chromosome 1p and 11q deletions, truncating or structural variants of ATRX gene (Cheung et al., 2012; Molenaar et al., 2012), genomic rearrangements of TERT (Peifer et al., 2015; Valentijn et al., 2015).