Consistently, we found that osteoclastogenesis is supported by CD14+ monocytes, CD8+ T-cells, and neutrophils from MM-bone disease patients by means of an elevated production of the TNF superfamily member LIGHT/TNFSF14 (homologous to lymphotoxin exhibiting inducible expression and competing with Herpes Simplex Virus glycoprotein D for Herpesvirus entry Mediator [HVEM], a receptor expressed by T lymphocytes) (14). This evidence concerns the gene TNFSF14 and Miyoshi myopathy.