Repeated Pf infection among Ugandan children was associated with reduced percentages of Vδ2+ γδ T cells, decreased pro-inflammatory cytokine production in response to malaria antigens, and increased expression of CD16 and CD57 and immunoregulatory genes such as HAVCR2 (encoding the inhibitory receptor Tim-3) (34) (Figures 1, 2B). The gene discussed is HAVCR2; the disease is malaria.