Although IgA N-glycosylation was shown to influence the IgA transport from circulation to mucosal tissue (11) and the O-glycosylation of IgA1 is considered a major factor in the pathogenesis of IgA nephropathy (12), the absence of the Fc N-glycosylation of IgA1 had no effect on FcαR binding (13). This evidence concerns the gene CD79A and IgA glomerulonephritis.