TSSK1B and systemic sclerosis: Treatment with TAK242 exerted potent antifibrotic effects in both bleomycin-induced skin fibrosis that recapitulate the inflammatory stage of SSc in fibrotic skin (20) and in the Tsk1/+ mice that resembles non-inflammatory SSc (5), and attenuated the constitutively-activated phenotype of SSc fibroblasts in culture.