Moreover, friend leukemia virus integration 1 (Fli1) -a predisposing factor of SSc- haploinsufficiency increases Th2- and Th17-like Tregs proportions in BLM-induced pro-fibrotic skin condition, in which IL-33-producing dermal fibroblasts contribute to Th2-like Tregs trans-differentiation (71). This evidence concerns the gene FLI1 and systemic sclerosis.