APOH and autoimmune polyendocrinopathy: Clearly these experiments must be done before clinical application of PEG-DI can be considered, furthermore, we also plan to test ability of PEG-DI to inhibit thrombus formation in a chronic mouse model of APS, in which mice are immunized with human β2GPI and thus develop their own anti-β2GPI antibodies (34) (as opposed to the passive transfer of human APS-IgG reported in this paper).