Within the most up- or downregulated genes are factors that are clearly related to apoptosis (TP53BP2, CSRNP1, TEAD3, CDCA7, PPP1R15A), immune response (OSM, AMPD3, BTLA, SKAP2, IGSF6, LST1, FGR, MAPK13), regulation of inflammatory response (CD40, S100A12, ADGRE3, TREM1, STEAP4, NR4A3), DNA replication and repair (FEN1, HIST1H4L), cell growth (ARID5A, VPS37B, HGF, CSF3R), cell adhesion and cell-cell signaling (NRXN2, CLEC12A, AREG), nervous system development (RAPGEF5, CASZ1, EGR2, L1CAM), and a gene involved in the pathogenesis of Alzheimer's disease (APBB1). The gene discussed is MAPK13; the disease is early-onset autosomal dominant Alzheimer disease.