INS and nicotine dependence: Lung cluster showed high expression levels of genes involved in nicotine addiction, biosynthesis of unsaturated fatty acids, long-term potentiation, glycosaminoglycan biosynthesis - heparan sulfate/heparin, cell adhesion molecules, insulin secretion, GABAergic synapse, fatty acid metabolism, amyotrophic lateral sclerosis, and adrenergic signaling in cardiomyocytes.