To explore the association of Type III IFNs with Strongyloides stercoralis (Ss) infection, we examined the systemic levels of IFN lambda-1, IFN lambda-2 and IFN lambda-3, IL-10, and CXCL10/IP-10 in Ss infected (INF, n = 44), helminth—uninfected (UN, n = 44) and in post-treatment INF individuals. Here, CXCL10 is linked to synovial sarcoma.