PIK3CD and lymphoproliferative syndrome: PI3K/Akt signaling is stimulated in several herpesvirus-associated lymphoproliferative disorders, including EBV-induced T-cell lymphocytosis, Kaposi’s sarcoma, Hodgkin’s lymphoma, and nasopharyngeal carcinoma (Benetti and Roizman, 2006; Alsayed et al., 2008; Chen, 2012).