Reassuringly in preclinical studies for psoriasis (a chronic inflammatory skin disorder), a VLP-vaccine targeting the pro-inflammatory cytokine IL-17, we demonstrated that induced anti-IL-17 antibody levels reversed after cessation of immunization and stimulating an endogenous flare of the cytokine using imiquimod (a TLR7/8 ligand and potent IL-17 activator) was unable to influence antibody responses, as T cell help from the VLP was missing (Rohn et al., 2006; Zeltins et al., 2017). The gene discussed is IL17A; the disease is psoriasis.