Indeed, in 2006 Gnecchi et al. published a pivotal study demonstrating that Akt-overexpressing MSC produced a cardioactive secretome by conditioning their culture medium, which exerted remarkable beneficial cardioprotective effect when administered to a preclinical rodent model of acute MI (Gnecchi et al., 2006). The gene discussed is AKT1; the disease is myocardial infarction.