SLC8A1 and type 1 diabetes mellitus: Decreased activity of the Na+/K+ pump (Greene, 1986; Kjeldsen et al., 1987; Hansen et al., 2007) and Na+/Ca2+ exchanger (Chattou et al., 1999; Hattori et al., 2000) were reported in hearts from animals with type 1 diabetes (T1DM).