Fibroblasts from patients with LGMD1B (Muchir et al., 2003), autosomal dominant EDMD (Muchir et al., 2004), L-CMD (Tan et al., 2015), DCM (Muchir et al., 2004), familial partial lipodystrophy (FPLD) (Vigouroux et al., 2001; Verstraeten et al., 2009), Mandibuloacral dysplasia (MAD) (Novelli et al., 2002), Hutchinson-Gilford progeria syndrome (HGPS) (Eriksson et al., 2003), and Werner syndrome 2 (WRN2) (Chen et al., 2003) all have nuclear abnormalities, such as abnormal nuclear shape and mislocalization of lamina proteins. The gene discussed is LMNA; the disease is mandibuloacral dysplasia.