In addition to Sema3A, Sema3E, Sema4D, and Sema7A that have been extensively described for their role in the development of atherosclerosis, other members of the semaphorin family are potentially involved in atherogenesis due to their role in endothelial activation and dysfunction, neovascularization, and immune response. Here, SEMA4D is linked to atherosclerosis.