SEMA4D and hyperlipidemia: Luque et al. (2013, 2015) showed that Sema4D is expressed in plaque macrophages and foam cells and mediates monocyte-endothelial cell adhesion by interacting with its receptors, PlexinB2 and PlexinB1, implying that non-platelet Sema4D may participate in atherogenesis as well. However, Zhu et al. (2007, 2009) did not observe the reduction in the infiltration of Sema4D-expressing cells, including T cells, B cells, and monocytes/macrophages in atherosclerotic lesions when investigating whether the reduction of hyperlipidemia is by the global absence of Sema4D.