Interestingly, similar to previous observations, ICS II treatment for 28 days clearly decreased BCCAO-induced expression of APP and BACE1, leading to the reduction of Aβ levels in VD, indicating the prevention of the amyloidogenic pathway in APP processing is benefit for the inhibition of Aβ generation in the neuropathological mode of CCH. The gene discussed is APP; the disease is columnar cell hyperplasia of the breast.