Furthermore, according to the continuous series of in-depth studies by Gu Weiliang on Radix Scrophulariae (Gu et al., 2010; Huang et al., 2012), the results showed that angoroside C has beneficial effects against ventricular remodeling, and the mechanism is likely to be related to decreasing the level of Ang II, attenuating the mRNA expressions of endothelin 1 (ET-1) and transforming growth factor β1 (TGF-β1) (Gu et al., 2015), which is effective in postponing heart failure for patients with cardiovascular illness. Here, EDN1 is linked to heart failure.