For example, HSD11B2 [Corticosteroid 11-beta-dehydrogenase isozyme 2] is the target mainly perturbed by RC and is involved in the activation of synthetic glucocorticoids and modulation of intracellular glucocorticoid levels, that is also one of the main drugs to treat RA (Orsida et al., 2002; Mullins et al., 2015). The gene discussed is HSD11B2; the disease is rheumatoid arthritis.