It was proposed that DNA hypomethylation occurs with high expression of DNMTs because of the inhibition of de novo methylation through DNMT3 and post- translational degradation of the enzymes, via a class of proteins (UHRF1 and UHRF2) that have been frequently overexpressed in cancer and emerged as epigenetic regulators during DNA replication (Jia et al., 2016). The gene discussed is UHRF1; the disease is cancer.