AKT1 and Decreased liver function: The pathways related to mTOR signaling in the pathogenesis of hepatopathies include the LKB1/AMPK/mTOR metabolic axis, PI3K/AKT/mTOR and Bcl-2/Bax-mediated apoptosis/autophagy, and ERK/mTOR-mediated autophagy, the AKT/mTOR/c-Myc axis, NF-κB/mTOR signaling and TSC/mTOR signaling (Bhangoo et al., 2017; Chang et al., 2017; Li et al., 2017; Wang et al., 2017; Hu et al., 2018; Majd et al., 2018; Wei et al., 2018).