In contrast, in older 18-month iTG rats that had been infected with E. coli at 8, 11, 14, and 17 months of age, no changes in Piezo1 channel expression were measured in prefrontal (12 ± 2%; Figure 5K) or frontoparietal (12 ± 3%; Figure 5L) cortices compared to non-infected TgF344-AD counterparts. Here, PIEZO1 is linked to Alzheimer disease.