In the present study, the age-dependent increases in Piezo1 channel expression measured in the prefrontal cortex, CA1 and DG of wild-type rats appeared predominantly neuronal whereas in the TgF344-AD rat model, peripheral infection and amyloid plaque pathology caused an upregulation of Piezo1 predominantly in reactive astrocytes, although concomitant increases in neurons and reactive microglia are also likely to occur. The gene discussed is PIEZO1; the disease is amyloidosis.