This bacterial infection caused a significant upregulation of Piezo1 channels in the prefrontal (21 ± 3%; Figure 5K) and frontoparietal (23 ± 3%; Figure 5L) cortices of 12-month old iTG rats, but not the audiovisual cortex (16 ± 2%; Figure 5M). Here, PIEZO1 is linked to bacterial infectious disease.