ITGAM and cancer: Furthermore, tongues from 4NQO-treated mice receiving αLy6G also had a significant increase in CD11b+Ly6G− monocyte/macrophage infiltration into the cancer microenvironment compared to IgG2A-treated mice (154.9 ± 36.7%, P = 0.028, One-way ANOVA; Figure 8C) suggesting a compensatory response to the αLy6G-induced decrease in neutrophil infiltration.