In particular, chronic EAE induced by MOG peptide in mice showed, although with some variability, intracortical MS-like lesions characterized by diffused demyelination, astroglial and microglial activation, oligodendrocyte precursor cells (OPC) proliferation, and a low leukocyte/macrophage infiltrate (Girolamo et al., 2011; Mangiardi et al., 2011; Hasselmann et al., 2017). This evidence concerns the gene MOG and myeloid sarcoma.