KCNMB2 and Menkes disease: Our previous study showed that excessive paternal methyl donor intake prior to mating results in Kcnmb2 promoter hypermethylation associated with reduced Kcnmb2 expression which may relate to LTP deficits, abnormalities in hippocampal theta oscillations as well as spatial learning impairments in MD F1 offspring mice (Ryan et al., 2017).