In contrast, the early LTP in the SC-CA1 synapses of MD F1 mice receiving AAV-Kcnmb2 injection (MD-Kcnmb2) was comparable to that recorded in both CD-Kcnmb2 and CD-control mice (two-way ANOVA followed by Tukey’s multiple comparisons test, P > 0.05), indicating that virus-mediated overexpression of Kcnmb2 abolished early LTP alteration in SC-CA1 synapses of MD F1 offspring, but had no significant effect on CD F1 mice. This evidence concerns the gene KCNMB2 and Menkes disease.