Post-ischemic NOS2 is expressed in leukocytes and brain endothelial cells of rodents and humans (Iadecola et al., 1996; Nathan, 1997; Forster et al., 1999; Niwa et al., 2001; Garcia-Bonilla et al., 2014), though decreasing NOS2 expression in leucocytes alone is insufficient to improve stroke outcomes (Garcia-Bonilla et al., 2014). Here, NOS2 is linked to stroke disorder.