PLAT and Stroke: Though many compounds improve outcomes in animal stroke models, none have been effective in human stroke trials (Stroke Therapy Academic Industry Roundtable [Stair], 1999; DeGraba and Pettigrew, 2000; Richard Green et al., 2003; Young et al., 2007; Grupke et al., 2014), except for r-tPA (Fagan et al., 1998; Morris et al., 2001; Gropen et al., 2006).