Moreover, TPO/TgAb positivity and US positivity also had a significantly association with obesity in both genders (male: OR 1.982, 95% CI 1.149, 3.420, P = 0.014; female: OR 1.601, 95% CI 1.145, 2.238, P = 0.006). Here, TPO is linked to obesity due to melanocortin 4 receptor deficiency.