In the primary tumours, immune subtype associated with age (p = 0.047) and nuclear HIF1a (p = 0.043); canonical subtype associated with cytoplasmic MMP9 expression (p = 0.015); latent subtype associated with marginal involvement (p = 0.013); and stromal subtype associated with modified Glasgow Prognostic Score (p = 0.044) and cytoplasmic HIF1a expression (p = 0.012). Here, HIF1A is linked to neoplasm.