ELTD1 was expressed in breast cancer cell lines to assess the effect on tumour growth in xenograft experiments and knockout mice were generated with 1) tamoxifen-inducible knockout of Eltd1 in all tissues 2) constitutive Eltd1 knockout in vessels or 3) inducible Eltd1 knockout in vessels. This evidence concerns the gene ADGRL4 and neoplasm.