GCG and metabolic dysfunction-associated steatohepatitis: In particular, cell cycle, inflammation, hemostasis and platelets, ER stress and proteasome, amino acid and purine metabolism, DNA damage and apoptosis gene sets were down-regulated in livers from M+Fc-GLP-1 versus MCD mice, suggesting that multiple pathways dysregulated in NASH were modulated by Fc-GLP-1 treatment (Fig. 1c and Supplementary Table 2).