However, contrary to the beneficial effects of Fc-GLP-1 in the reversion of NASH-like features before PH (Fig. 1a,b), reduced efficacy of Fc-GLP-1 on liver disease was evident in the M + Fc-GLP-1 mice at 2 weeks post-PH (Fig. 3c–e), although the microarray analysis revealed up-regulation and enrichment in gene sets related to NASH in MCD versus M + Fc-GLP-1 group (Supplementary Table 3). This evidence concerns the gene GCG and metabolic dysfunction-associated steatohepatitis.